IMPACTS - Archive's tissues: improving molecular medicine research and clinical practice
Research fields:
Period: 01/03/2007 - 28/08/2009 Research description:
Nowadays, emerging capabilities are being introduced to a more
personalized molecular approach in medicine with individual risk
assessment and best suited care. An important tool for translational
research in this field is the large number of human archive tissues
(AT), with any kind of disease, stored in hospitals all over Europe.
Tissues from biopsies or surgical therapy are fixed and paraffin
embedded to obtain a histopathology diagnosis, and then stored in
archives for many decades. We developed already the technology that
allows molecular research at DNA and RNA level in paraffin embedded
tissues, so that the findings can be evaluated in the proper context.
These methods were first designed by European scientists. In this way
it is easy to study lesions with long follow-up, rare diseases, viral
persistence or molecular pattern of lesions with known therapy
outcomes. There is the opportunity of an European Coordination Action
in advanced genomics to impr ove and speed up clinical applications for
health and also for R&D of European biotechnology companies. The
objectives of this CA are: a) to prepare molecular methods validation
and standardization for AT; b) dissemination of standardized methods
for functional genomics at European level with good practice rules; c)
prepare future perspectives at clinical, research and technology level;
d) establish bioethics guidelines for utilization of human archive
tissues in research; e) organize tissues banks for translational
research; f) promote technology innovation and industrial
collaboration. Expected results of the Action are integrating European
molecular research with a faster dissemination and application of
molecular methods in clinical practice, preparing the opportunity of
new multicentric functional genomics research projects, stimulating
technology innovation with industrial collaboration in the fields of
gene expression analysis and proteomics
| Keywords: |
human archive tissues (AT), methods |
| Project type: |
EU |
| Total cost: |
600000 |
| Approved funding: |
600000 |
|