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Avedas AG  
 
Competences in Nanomedicine
Advanced genomics and its applications for health
Biopharmaceutics
Drug Delivery
Drug Encapsulation
Functional Drug Carriers
Drug Discovery
Implantable Materials
Implantable Devices
Surgical Aids
Diagnostic Tools
Commercialisation
Materials
BRIDGE
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Drug Delivery

Nanotechnology provides a wide range of new technologies for developing customized
solutions that optimize the delivery of pharmaceutical products.

To be therapeutically effective, drugs need to be protected during their transit to the
target action site in the body while maintaining their biological and chemicals properties.
Some drugs are highly toxic and can cause harsh side effects and reduced therapeutic
effect if they decompose during their delivery. Depending on where the drugs will be
absorbed (i.e. colon, small intestine, etc), and whether certain natural defense
mechanisms need to be passed through such as the blood-brain barrier, the transit time
and delivery challenges can be greatly different.


Once a drug arrives at its destination, it needs to be released at an appropriate rate for it to
be effective. If the drug is released too rapidly it might not be completely absorbed, or it
might cause gastro-intestinal irritation and other side effects. The drug delivery system
must positively impact the rate of absorption, distribution, metabolism, and excretion of
the drug or other substances in the body. In addition, the drug delivery system must
allow the drug to bind to its target receptor and influence that receptor's signalling and
action, as well as other drugs, which might also be active in the body.

Drug delivery systems also have severe restrictions on the materials and production
processes that can be used. The drug delivery material must be compatible and bind
easily with the drug, and be bioresorbable (i.e. degrade into fragments after use which are
either metabolized or eliminated via normal excretory routes). The production process
must respect stringent conditions on processing and chemistry that won't degrade the
drug, and still provide a cost effective product.


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Publications (3)
Persons (1)
Organisations (1)


A ceramic drug delivery vehicle for oral administration of highly potent opioids.
Prof. Håkan Engqvist
Pellets composed of the ceramic material Halloysite and microcrystalline cellulose were synthesized with the aim of producing a drug delivery vehicle for sustained release of the opioid Fentanyl with low risk for dose dumping at oral intake of the highly potent drug. Drug release profiles of intact ...
Technique for preparation and characterization in cross-section of oral titanium implant surfaces using focused ion beam and transmission electron microscopy.
Prof. Håkan Engqvist
The surface properties of materials are believed to control most of the biological reactions toward implanted materials. To study the surface structure, elemental distribution, and morphology, using transmission electron microscopy (TEM) techniques, thin foils of the surface (in cross-section) are ...
Three-dimensional technology and bone morphogenetic protein in frontal bone reconstruction
Prof. Jöns Hilborn
Osteoinductive bone morphogenetic proteins (BMPs) may be used in humans to facilitate healing of bony defects. The effect of different BMPs is, as with many other growth factors, highly dependent on the delivery vehicle. Bovine type I collagen is currently used in the clinical setting as a carrier ...

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